Although not significant, we observed a strong trend towards reduction of LV mass index also in the medically treated group, with a median follow-up time of less than two years.
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Cardiac magnetic resonance imaging of myocardial mass and fibrosis in primary aldosteronism.
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The sentences
For both PA1 and HS, the contrast enhancement showed a trend towards reduced values from 2 to 14 min post-contrast.
One echocardiographic study showed no significant change of LV mass index one year after start of mineralocorticoid receptor antagonist treatment, whereas another large study showed borderline significant reduction in LV mass index in medically treated PA after a median follow-up of 36 months ( 21 , 22 ).
When analysing the adrenalectomized ( n = 8) and the medically treated ( n = 6) PA1 patients separately, the adrenalectomized patients had a larger and highly significant reduction of LV mass index, compared with the medically treated patients who showed a trend towards, but had no significant reduction in LV mass index (adrenalectomized PA1 median reduction of LV mass index −9 g/m 2 ; P = 0.003 vs mineralocorticoid receptor antagonist treated PA1 reduction of LV mass index −5 g/m 2 ; P = 0.075, not shown).