Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes.

Although these differences did not reach statistical significance, these findings indicate that TRIF signaling exerts a protective effect and delays the development of islet autoimmunity.

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Mice with myeloid cell specific TIR-domain-containing adapter-inducing interferon-β (TRIF) knockout showed a trend towards accelerated onset of STZ-induced diabetes, while TRIF deficiency resulted in reduced IDO expression in vivo and in vitro .

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