Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.

A significant association was determined if (1) the p -value for the cross-trait meta-analysis reached genome-wide significance ( p < 5 × 10 −8 ) and (2) the univariate GWAS effects were at least nominally significant ( p < 0.05).

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Constantly, results after 8 weeks of treatment showed a trend inverse association between the PGS for neurotic personality and SSRIs treatment remission, although this was not statistically significant (Figure 2 C).

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