Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy.

Paroxetine and promethazine showed a trend toward ameliorating arsenite-induced FUS-eGFP SG phenotypes in SL P525L neurons ( Figure 7 E), although the effect did not reach statistical significance.

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When paroxetine, promethazine, and trimipramine were tested in the context of a milder and more physiological phenotype, such as that of P525L LL neurons, they produced a highly significant reduction of FUS-eGFP SG intensity ( Figures 7 F and 7G) and size (data not shown).

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