No statistically significant effect of 5-aza-dC was observed on repressive histone mark H3K27me3 at either of the positions, while VPA showed a trend to increased enrichment at positions -2 and -1, which did not reach statistical significance, however (Figure 5B ).
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Epidrug-induced upregulation of functional somatostatin type 2 receptors in human pancreatic neuroendocrine tumor cells.
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Treatment of BON-1 cells with 5-aza-dC lowered the EC 50 for the inhibitory effect of octreotide treatment on cAMP levels from 60 nM in untreated control cells to 18 nM in 5-aza-dC treated cells, indicating an enhanced effect of octreotide treatment at the level of cAMP inhibition (Figure 3A, 3B ), although this difference did not reach statistical significance.