Among the Metabochip previously known BMI loci that failed to replicate, the meta-analysis p-values approached significance, with most in the 10 −4 range.
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Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI.
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The sentences
Of the six loci that did not reach statistical significance in our own study, two of these had lead SNPs that were very rare, with CAF<0.01 in 1000 Genomes populations and PAGE racial/ethnic subgroups.