Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy.

However, a clear trend toward a dose-related force increase in treated muscle was observed, with a similar level of force production obtained by both laboratories ( Table 3 and Supplemental Table 4S ).

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In addition, the experiments at UNIBA showed that the effect of S48168/ARM210 on EDL muscle were slightly stronger after the long-term study than after the short-term investigation, although this difference did not reach statistical significance.

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