Multicolour flow cytometry showed a trend for NK cell activation in the patients (n=3) compared with age-matched healthy controls (n=3), based on higher frequency of surface activating and cytotoxic receptors.
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Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors.
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The differences did not reach statistical significance, perhaps due to small sample size (see online supplementary figure 2A–C ).