Anti-O-specific polysaccharide (OSP) immune responses following vaccination with oral cholera vaccine CVD 103-HgR correlate with protection against cholera after infection with wild-type Vibrio cholerae O1 El Tor Inaba in North American volunteers.

PLoS Negl Trop Dis · 2018 · PMC5906022 · PMID 29624592

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0.0600

closest p · 1.2× alpha

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boldest claim

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approaching significanceP = 0.06so close (0.05 < p ≤ 0.1)

We found similar results when considering day 10 anti-Inaba OSP responses and protection from any degree of diarrhea, with differences in mean values approaching significance for both IgM ( P = 0.06) and IgA ( P = 0.05) ( S2 Fig ).

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approached significanceP = 0.06so close (0.05 < p ≤ 0.1)

We found that IgM anti-OSP Inaba responses on day 10 following vaccination with CVD 103-HgR correlated with protection against moderate or severe diarrhea following subsequent experimental challenge (moderate or severe diarrhea versus no diarrhea; P = 0.01; Fig 4 ), and that day 10 IgA anti-OSP responses approached significance in this analysis ( P = 0.06; Fig 4 ).

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