PICP:ICTP evaluation reveals a clear trend (significant only after adjustment for bone turnover [ P =0.012]) of prevalent type I collagen synthesis over degradation within the subgroups of FD patients with greater severity (Figure S1 ).
Moreover, there was a significant trend of decreased activity of MMP1 as severity increased.
The serum concentration of PICP and PICP adjusted for bone turnover was significantly higher in male patients, and there was a nonsignificant trend of lower serum MMP1 concentration in the same sex.