Canonical NF-κB signaling in myeloid cells promotes lung metastasis in a mouse breast cancer model.

Interestingly, although containing lower numbers of CD68 + cells compared to metastatic PyMT Ikkβ Δmye mice, lungs from tumor free Ikkβ Δmye animals showed a clear trend towards increased presence of CD68 + cells as well.

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Some of the inflammatory mediators that were found elevated in the lungs of tumor-free Ikkβ Δmye animals (Figure 4A ) also showed a trend towards slightly increased expression in the mammary glands of tumor-free Ikkβ Δmye animals and Il1b expression was significantly higher ( Supplementary Figure 2 ).

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