Plasma and memory B cell responses targeting O-specific polysaccharide (OSP) are associated with protection against Vibrio cholerae O1 infection among household contacts of cholera patients in Bangladesh.

Vibriocidal titer has been considered as the surrogate marker of protection against cholera, and therefore, when considering only contacts with baseline vibriocidal values of 1:80 or lower, the presence of LPS IgG memory B cells was also significantly associated with a decreased risk of infection in contacts, and the risk reduction when OSP IgG memory B cells were present approached significance (OSP: risk ratio 0.62; 95% confidence interval [CI] 0.350 to 1.100; LPS: risk ratio 0.62; 95% confidence interval [CI] 0.384 to 0.987).

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We also note higher baseline memory B cell IgA and IgM OSP values and protection among household contacts compared to infected contacts, although these differences did not reach statistical significance in our current study.

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