Balancing the high level of baseline premature responding in the PCP and 1 mg/kg aripiprazole group (by removing two animals from this group) with that of all other groups at baseline diminished the interaction, and the effect just failed to reach statistical significance [ F (3, 30) = 2.78, p = 0.058].
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The Effects of Cariprazine and Aripiprazole on PCP-Induced Deficits on Attention Assessed in the 5-Choice Serial Reaction Time Task.
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0.0580
0.1800
The sentences
approached significancep < 0.1
No significant effect was observed for reward latency, although a main effect of Day approached significance [ F (1, 32) = 3.66, p < 0.1] (Table 2 ).
failed to reach significancep = 0.18
Although the day × treatment interaction for percent incorrect responding failed to reach significance [ F (3, 30) = 1.75, p = 0.18], preplanned comparisons demonstrated that PCP alone significantly increased incorrect responding compared to baseline ( p < 0.01; Fig. 2 a, Table 2 ).
While there was an apparent dose-dependent reduction in premature response in aripiprazole-treated animals, the interaction for this measure did not reach statistical significance.