Beneficial Outcome of Urethane Treatment Following Status Epilepticus in a Rat Organophosphorus Toxicity Model.

Exposure of rats to an SE-producing dose of soman was reported to increase anxiety behavior ( Apland et al., 2014 ; Prager et al., 2014, 2015 ), whereas exposure to sub-SE doses of other OP agents showed a trend toward decreased anxiety behaviors ( Schulz et al., 1990 ; Wright et al., 2010 ) or had no effect ( Nieminen et al., 1991 ; Valvassori et al., 2007 ).

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A strong trend for reduced CD11B mRNA was also observed in the brains of urethane-treated rats [3.1 ± 0.5 ( n = 9 rats) for diazepam vs 1.6 ± 0.2 ( n = 13 rats) for urethane], although statistical significance was not attained ( p > 0.05, one-way ANOVA with post hoc Bonferroni r ; Fig. 7 C ).

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