High-throughput analysis of the RNA-induced silencing complex in myotonic dystrophy type 1 patients identifies the dysregulation of miR-29c and its target ASB2.

As a confirmation of the additional insight provided by this approach, most miRNA dysregulations identified in the RISC did not reach statistical significance when total RNA was analyzed.

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Of note, most miRNAs differentially modulated in the RISC of DM1 patients displayed similar trends, but failed to reach statistical significance, in total RNA counterparts (Supplementary Table S4 ), confirming the additional insight provided by the analysis of RISC-associated RNAs.

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