Preclinical Testing of an Oncolytic Parvovirus in Ewing Sarcoma: Protoparvovirus H-1 Induces Apoptosis and Lytic Infection In Vitro but Fails to Improve Survival In Vivo.

Viruses · 2018 · PMC6024310 · PMID 29865280

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

did not reach statistical significancep = 0.08so close (0.05 < p ≤ 0.1)

Eleven days after treatment, the animals treated with empty capsids had a mean tumor volume of 1190 mm 3 , whereas the mean tumor volume in the H-1PV-infected animals was 752 mm 3 ; however, this virus-induced repression of tumor cell proliferation did not reach statistical significance ( p = 0.08).

also in 111,027 other papers

failed to reach statistical significanceno p-value reported

Although virus-triggered repression of tumor proliferation was also observed in a Ewing sarcoma xenograft model, this in vivo antineoplastic effect failed to reach statistical significance and to translate into improved survival. 2.

also in 6,035 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.