The somatic mutation landscape of premalignant colorectal adenoma.

Gut · 2018 · PMC6031265 · PMID 28607096

Europe PMC DOI

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did not reach statistical significanceno p-value reported

A closer examination of 96 CRCs with mutation frequencies less than or equal to that of adenomas demonstrated that three of the five CNAD driver genes ( KRTAP4-5 and TMPRSS13 and APC ) showed driver patterns as well while two genes ( CTNNB1 and GOLGA8B ) did not reach statistical significance as driver genes possibly due to smaller sample size (online supplementary figure 2 ).

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a clear trendno p-value reported

Furthermore, genes with a clear trend towards malignancy could serve as molecular ‘clocks’ to indicate how far an adenoma has progressed towards tumourigenesis.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.