Enhanced Bone Metastases in Skeletally Immature Mice.

Although bioluminescence imaging showed a trend toward greater overall proliferation of AT3-FL breast cancer cells in young mice, these differences did not reach statistical significance as defined by P < .05 ( Figure 2, A and B ).

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While imaging showed a trend for higher initial signal from breast cancer cells in the distal tibia, differences between proximal and distal portions of this bone were not significant ( Figure 1, C and D ).

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