Although a clear trend can be observed, a huge variability in PPI was observed amongst different registries, even when the same valve was involved (Figure 2) ( 1 , 22 – 25 , 27 , 29 – 31 , 49 , 51 – 75 ).
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The sentences
A smaller recent study of 1,973 patients from the PARTNER trial ( 91 ) and an international multicentre registry noted a trend toward increased 1-year mortality in patients with new PPI, but it did not reach statistical significance ( 92 ).