Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension.

Mdivi-1 (25 μM) for 3 days significantly reduced type III collagen production in MCT-RVfib, while P110 (1 mM) for 3 days showed a trend ( P = 0.14) in reducing type III collagen production in MCT-RVfib ( Figure 3 ).

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Consistent with this we found an increase in the phosphorylated Drp1 at Serine 616 ( Figures 4A – D ) and a strong trend to decreased MFN2 expression (Supplementary Figures S3 , S4 ) in RVfib in MCT-PAH, without significant changes in the other two fusion mediators (MFN1 and OPA1) (Supplementary Figure S3 ).

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