Endocrine cell type sorting and mature architecture in the islets of Langerhans require expression of Roundabout receptors in β cells.

Analysis of β cell area in Ucn3-Cre;Robo1 Δ/Δ , 2 flx/flx islets showed a trend towards larger β cell area in the Robo KO when compared to controls though this did not reach statistical significance, further pointing against β cell death in Robo KO mice as an explanation for the islet architectural defects (Fig. 5B ).

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The average islet size of Ucn3-Cre;Robo1 Δ/Δ , 2 flx/flx shows a slight trend towards larger islet than those of controls, but this trend does not reach statistical significance (18157 μm 2 and 21968 μm 2 , respectively, P = 0.1653, n = 10–20 islets each for four independent mice in each genotype) (Fig. 3F ).

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