Running on mixed fuel-dual agonistic approach of GLP-1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non-human primates.

However, the extent of increase in response to the dose of GCG used was of only marginal significance, and was of longer duration when insulin secretion was inhibited by somatostatin.

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Increasing the dual agonist dose to 100 μg/kg increased glucose excursion compared to vehicle‐treated controls, but the increase did not reach statistical significance.

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Plasma FGF21 levels showed a trend toward an increase in dual‐agonist‐treated vs liraglutide‐ or vehicle‐treated mice (Figure 6 C). 3.1.1.

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