Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis.

In classical AS, there was a strong trend toward increased N2BA proportions, whereas in ASrEF, a relatively low degree of titin-isoform shift was found, despite pronounced fibrosis in all AS subtypes.

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The subgroup pAS showed a trend for hypophosphorylation at S4185, compared with donor hearts and cAS, whereas the ASrEF subgroup was significantly hypophosphorylated at S4185 versus donors ( Table 4 , Figure 4C ).

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