Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain.

Sci Rep · 2018 · PMC6063949 · PMID 30054579

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did not reach statistical significanceno p-value reported

In the short HFD feeding group, Hes3a, Hes3b, Hes1, but not Hes5 expression were reduced, relative to the short normal diet (ND) feeding group; in the long HFD feeding group, Hes3a and Hes3b expression showed a tendency to decrease, compared to the long ND feeding group, but did not reach statistical significance.

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showed a trendno p-value reported

Regarding energy metabolism, indirect calorimetry showed no differences in ND, whereas NMR showed a trend towards increased fat content over time mainly in male mutants.

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