Glutamatergic Signaling Drives Ketamine-Mediated Response in Depression: Evidence from Dynamic Causal Modeling.

This parameter also approached significance with the sustained change in MADRS scores from baseline to Day 11 post-ketamine infusion (r=0.3900, P= .05) ( Figure 3B ).

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When comparing change in depression rating scale scores across time, longer lasting effects were observed for AMPA-mediated connectivity relative to NMDA connectivity, with the correlation between AMPA estimates post-ketamine and improved mood approaching significance at even 11 days postinfusion.

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