Biomarker Evaluation and Toxic Effects of an Acute Oral and Systemic Fumonisin Exposure of Pigs with a Special Focus on Dietary Fumonisin Esterase Supplementation.

The impact of group was primarily reflected in elevated values for FUM po compared to the other groups (CON: 67.94 a , FB1 iv : 70.48 abc , HFB1 iv : 70.68 ab , FUM po : 73.40 b , FumD po : 65.50 c mg/dL; post hoc Student’s t -test p < 0.05), whereby the most pronounced difference was apparent to the enzyme-treated group FumD po ( post hoc Student’s t -test, p < 0.001).

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Significant differences for group and time were obtained for total cholesterol ( Figure 6 a) and a marked trend for an interaction of group–time was also observed.

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The contrasting time kinetics of sphinganine and Sa/So ratio between fumonisin groups FB1 iv and FUM po on one hand and groups CON, HFB1 iv , and FumD po on the other hand were the reason for the highly significant interaction between group and time.

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