Genetic inhibition of autophagy in a transgenic mouse model of anal cancer.

Of the K14CreER TM+/- /Atg7 f/f mice treated with DMBA and 4-OH Tam, 40% (six out of 15) developed SCCA compared to 0% (0 out of 16) of K14CreER TM+/- /Atg7 f/f mice treated with DMBA only, trending towards significance (Fisher's exact test P = 0.0068).

also in 515 other papers

As expected, mice treated with both 4-OH Tam and DMBA had lower LC3 β expression, although the mean difference in comparison with those mice treated with DMBA alone did not quite reach statistical significance [ Figure 2a ; mean ± SEM; 0.68 ± 0.14 vs. 0.38 ± 0.08; P = 0.078].

also in 679 other papers

In Figure 2 , there was a trend to a decrease in LC3β with Atg7 knockout, however it did not reach statistical significance.

also in 111,027 other papers