Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women.

For SNP rs5219 in KCNJ11 (HWE p = 0.004, WHO1999; HWE p = 0.01, WHO2013) and rs11605924 in CRY2 (HWE p = 0.007 WHO1999 and HWE p = 0.06, WHO2013), HWE values were nominally significant for the same criteria where an association was observed; these findings need to be replicated in independent cohorts.

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Of 6 loci previously associated with insulin resistance, here 3 also showed an association with HOMA2-IR and a trend towards significance for GDM2013 but not GDM1999 including SNPs rs7607980 in the COBLL1 gene [ 40 ], rs13389219 near GRB14 and rs10423928 in the GIPR gene indicating that some of the genetic basis seem to be driven by previously reported insulin resistance loci.

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SNPs rs7607980 near COBLL1 ( p = 0.0001), rs13389219 near GRB14 ( p = 0.026) and rs10423928 in the GIPR gene ( p = 0.012) as well as the genetic risk score (GRS) for these previously shown insulin resistance loci here associated with insulin resistance defined by HOMA2-IR and showed a trend towards GDM.

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