A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers.

Nat Commun · 2018 · PMC6086912 · PMID 30097571

Europe PMC DOI

hedged sentences

0.0900

closest p · 1.8× alpha

0.3100

boldest claim

The sentences

a clear trendP = 0.09so close (0.05 < p ≤ 0.1)

Notably, the group with a Type 3 TIL profile displaying elevated CD3+ TILs and high lymphocyte GZB and/or Ki-67 showed a clear trend toward better survival in this population ( P = 0.09, log-rank test, Fig. 5d ).

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did not reach statistical significanceP = 0.31not close (p > 0.1)

In addition, highly mutated tumors had 2.6-fold higher frequency of variants in genes associated with DNA repair (e.g., MLH3, MSH6, POLD1, POLE, etc.) than cases with low mutations, but this difference did not reach statistical significance (32% vs 12.5%, respectively, P = 0.31, Fisher’s extact test).

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