Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer's disease.

Transl Psychiatry · 2018 · PMC6092426 · PMID 30108205

Europe PMC DOI

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closest p · 1.6× alpha

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boldest claim

The sentences

did not reach statistical significancep = 0.08so close (0.05 < p ≤ 0.1)

The comparison of 5XFAD-Riluzole and 5XFAD controls revealed a trend towards reduction in riluzole-treated 5xFAD mice, however it did not reach statistical significance (Fig. 2i ; p = 0.08, Student’s t- test).

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showed a trendno p-value reported

In the present study, we found that riluzole treatment showed a trend towards reduction in human APP mRNA levels and a significant decrease in APP protein levels in 5XFAD mice.

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