Characteristics and Clinical Significance of De Novo Donor-Specific Anti-HLA Antibodies after Kidney Transplantation.

J Korean Med Sci · 2018 · PMC6097072 · PMID 30127706

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significanceP = 0.060so close (0.05 < p ≤ 0.1)

When the characteristics of DSA were analyzed according to type of DSA, the average MFI of DSA against HLA-DQ was higher than that of DSA against HLA-DR in terms of development of AMR, although this difference did not reach statistical significance (11,600.0 ± 978.6 vs. 7,448.1 ± 6,812.6; P = 0.060).

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showed a trendno p-value reported

However, considering that higher average MFI of DSA against HLA-DQ showed a trend, albeit not significant, for increased development of AMR, transplant clinicians should be alert regarding the formation of DSA against HLA-DQ with high affinity and increase the intensity of immunosuppressant therapy to the extent that no opportunistic infection occurs because the risk of AMR was significantly increased in the de novo DSA group compared to the persistently non-sensitized group.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.