Conversely, the mean spike rate within a burst and its mean duration showed a trend to decrease ( Figures 2E2 , F2 ; spike rate, SE: 6.33 ± 1.49 Hz; 1w: 5.56 ± 0.13 Hz; 2w: 4.71 ± 0.11 Hz; 3w: 4.24 ± 0.06 Hz; burst length, SE: 14.0 ± 1.66 s; 1w: 7.4 ± 0.2 s; 2w: 6.6 ± 0.1 s; 3w: 6.4 ± 0.1 s; refer to figure for P values).
← all excerpts
Position- and Time-Dependent <i>Arc</i> Expression Links Neuronal Activity to Synaptic Plasticity During Epileptogenesis.
3
—
—
The sentences
Epileptic mice also showed a strong trend towards a higher probability for induced behavioral seizures ( Figure 7I ; control: 3.1 ± 0.6%; epileptic: 5.3 ± 0.9), which appeared to depend on the spatial extent of the spontaneously epileptic network ( Supplementary Figure 7D ).
Interestingly, although the increase of spine size and density would have predicted an elevation of post-synaptic glutamate receptors ( Nusser et al., 1998 ; Takumi et al., 1999 ; Racca et al., 2000 ), we found a highly significant decrease of AMPARs by about 50% in the ipsilateral septal molecular layer ( Figures 5G – I ; optical density, control: 53.9 ± 0.7; KA, contra: 50.9 ± 2.4; KA, ipsi: 27.6 ± 2.4, P < 0.001), the same region where DGCs displayed (i) elevated Arc mRNA levels and (ii) showed the most prominent increase in spine number and size.