Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs.

4c ); by 8 h p.i., the difference was smaller (≈2-fold) but remained highly significant ( Fig. 4d ).

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In wt MEFs, growth of RRV-T48 A534V was slower than that of RRV-T48; however, the differences did not reach statistical significance with both viruses replicating to similar final titers.

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Nevertheless, there was a clear trend that replicases of viruses with slower processing of P123 induced significantly higher IFN-β levels than replicases of their counterparts having faster processing ( Fig. 6d ).

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