Decreased Hepcidin Levels Are Associated with Low Steady-state Hemoglobin in Children With Sickle Cell Disease in Tanzania.

[ 20 ] In American adults, serum hepcidin in heavily transfused SCD patients had a similar degree of correlation with serum ferritin but a larger negative correlation with EPO (r 2 = −0·34, p-0·03), which in our dataset, did not reach statistical significance – possibly due to the extremes of hemoglobin concentration resulting from our study design.

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Co-inheritance of an increasing number of α-thalassaemia mutations showed a trend for decreased odds of being in the Hb1Q group with two deletions having a significant protective effect (−α/−α deletion - OR 0·21; 95%CI 0·07–0·58), whilst increased fetal hemoglobin levels were similarly associated with decreased odds (OR 0·74; 95%CI 0·66–0·84).

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