TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease.

A significant increase in C99/Aβ trimer levels in both the RIPA and SDS fractions and a slight trend toward increased monomeric Aβ in the RIPA fraction of sTLR5Fc mice forebrain were noted (Fig.

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In a well-controlled behavioral study, we observed only a suggestive trend toward improved cognition in the fear context test and in burrowing behavior in the sTLR5Fc cohort.

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sTLR5Fc-expressing mice showed a trend toward reduced glial fibrillary-associated protein (GFAP; marker of astrocyte) and cd11b (marker of activated microglia) levels by immunoblotting compared with both EGFP- and Fc-expressing control mice (Fig.

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