Genetics of serum urate concentrations and gout in a high-risk population, patients with chronic kidney disease.

Table 3 shows results for the interaction between all SNPs and medications that showed at least a nominally significant (p < 0.05) SNP* medication interaction, namely thiazides and loop diuretics.

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When stratified by eGFR, the minor T allele of rs2231142 in ABCG2 was significantly associated with serum urate concentrations in each stratum and showed a trend for larger effects at eGFR values <30 ml/min/1.73 m 2 (Supplemental Table 5 ).

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