Permanent myocardial infarction induced cardiomyocyte death (characterized by neutrophil invasion and eosinophilia of nuclei-free dying cells) in a similar fashion to the observed infarcted area as seen by 18 F-FDG PET, although the difference between WT and mMCP-4 KO did not reach statistical significance in infarcted animals.
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Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction.
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The sentences
PMI showed a trend to increase left ventricular IR-ET-1 levels in WT mice, but this did not reach statistical significance (WT PMI: 0.111 ± 0.024 pg/mg, n = 7).