However, although the median polarisation ratio of TCR also was lower in Sh2d2a −/− T cells compared to Sh2d2a +/+ T cells displaying a maturing IS, this difference did not reach statistical significance (Fig. 2I ).
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Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd.
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These same cells showed a trend towards skewed Tem differentiation (Fig. 1F ).