Treosulfan Pharmacokinetics and its Variability in Pediatric and Adult Patients Undergoing Conditioning Prior to Hematopoietic Stem Cell Transplantation: Current State of the Art, In-Depth Analysis, and Perspectives.

Clin Pharmacokinet · 2018 · PMC6132445 · PMID 29557088

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showed a trendno p-value reported

Moreover, the Kaplan–Meier curve showed a trend towards better overall survival at high Cl tot of treosulfan (>8 L/h/m 2 ) and low AUC (< 1828 mg·h/L), although without statistical significance [ 25 ].

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did not reach statistical significanceno p-value reported

The odds of developing hepato- and neurotoxicity were also higher in the former group, but the difference did not reach statistical significance.

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