Skeletal muscle-derived cell implantation for the treatment of sphincter-related faecal incontinence.

Stem Cell Res Ther · 2018 · PMC6136163 · PMID 30213273

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did not reach statistical significanceno p-value reported

Although the reduction in WIE in the five male patients in the current study did not reach statistical significance, their Wexner and VAS scores did significantly decrease, suggesting that SMDC therapy might also be effective in male patients.

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a clear trendno p-value reported

Altogether, the responder analysis indicates a clear trend of decreasing FI severity and decreasing WIE over time in all patients.

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highly significantno p-value reported

Injection was very well tolerated and led to highly significant reductions in Wexner score and bowel movements as well as a marked improvement in the Fecal Incontinence Quality of Life (FIQL) score [ 21 ] after 1 year.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.