However, the data did not reach statistical significance due to the high variations in expression levels between cell lines.
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BRAF inhibition causes resilience of melanoma cell lines by inducing the secretion of FGF1.
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The sentences
Similar observations were obtained for M14 cells (with the exception of FGF1 , which is not induced in this cell line), and for UACC-62 cells, which showed a trend towards CCL2 and MMP2 upregulation as well as significant FGF1 induction under conditions of BRAF and/or MEK inhibition (Supplementary Figure 2A–E ).