Improved Induction of Anti-Melanoma T Cells by Adenovirus-5/3 Fiber Modification to Target Human DCs.

MART-1-specific CD8 + T cells stimulated by Ad5/3-MART-1-transduced MoDCs produced higher levels of IFN-γ in response to Mel-AKR than those stimulated by Ad5-MART-1-transduced MoDCs or MART-1 26–35L -pulsed MoDCs; however, this difference did not reach statistical significance ( Figure 2 a).

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Of note, CD8 + T cells primed with Ad5/3-MART-1-transduced DCs showed a trend towards higher production levels of the immunostimulatory cytokine IFN-γ in response to HLA-A2 + melanoma cells expressing MART-1 as compared to the other in vitro primed CD8 + T cells.

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