Hesperidin and capsaicin, but not the combination, prevent hepatic steatosis and other metabolic syndrome-related alterations in western diet-fed rats.

Animals fed a western diet showed a trend to lower locomotive activity compared to controls, but differences were not significant (Fig. 1a ).

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In turn, hesperidin treatment (100 mg/kg/day) attenuated body fat increase, as well as the increase in circulating leptin levels associated to western diet feeding, but the effects were lower than those observed by capsaicin and did not reach statistical significance.

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