Cross-Protective Immune Responses Induced by Sequential Influenza Virus Infection and by Sequential Vaccination With Inactivated Influenza Vaccines.

In the WIV vaccination group, depletion of CD4 or CD8 T cell did not significantly alter the weight loss compared with mock depletion but a strong trend toward less weight loss was observed in mice depleted for CD4 T cells as compared to non-depleted mice of this group ( P = 0.054, Figure 6A , WIV).

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Depletion of CD4 T cells decreased and depletion of CD8 T cells increased lung virus titers by about 1 log as compared to non-depleted animals on day 6 post challenge but these trends did not reach statistical significance (Figure 6B , WIV).

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