Baseline levels of type I collagen degradation (CTx) were observed to be more highly expressed in responders than non-responders, but did not reach statistical significance (0.48 (0.14–1.14) ug/L vs 0.31 (0.16–0.73) ug/L, p=0.07).
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Characterisation of circulating biomarkers before and after cardiac resynchronisation therapy and their role in predicting CRT response: the COVERT-HF study.
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CTx showed a trend towards predicting response and warrants further study.