Conclusion Both non-targeted and CCR2-targeting PEG-DSPE micelles showed a trend toward improving cardiac function.
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Effect of CCR2 inhibitor-loaded lipid micelles on inflammatory cell migration and cardiac function after myocardial infarction.
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The infarct area of mice treated with non-targeted micelles (18.0±3.6%) and CCR2-targeting micelles (17.2±4.6%) tended to decrease vs PBS controls (21.6±4.9%) but did not reach statistical significance ( Figure 5C ).