Genomic approaches in the search for molecular biomarkers in chronic kidney disease.

Eleven nominally significant SNPs were identified within four novel genomic loci, including variants in FRMD3 (p = 5.0 × 10 −7 ) and CARS ( p = 3.1 × 10 −6 ), which were also shown to contribute significantly to time needed to develop DKD ( FRMD3, p = 0.02 and CARS, p = 0.01) [ 54 ].

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Although no significant association with CKD progression could be found after correction for multiple testing, several candidate genes (including UMODL1 ) that had previously been related with CKD in the literature [ 96 , 98 , 100 ] showed a trend towards association with rapid CKD progression.

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