Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability.

Elife · 2018 · PMC6203434 · PMID 30226466

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

a negative trendp=0.055so close (0.05 < p ≤ 0.1)

The combined effect of TERT (rs72709458, rs2736100, rs2853676), TERC (rs10936600) and OBFC1 (rs1265164) had a negative trend with telomere length (p=0.055; linear model 95% CI −408.5 – 4.7 per one risk allele; see Appendix 1—figure 13 ).

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did not reach statistical significanceno p-value reported

In our patient cohort, the risk allele at TERT (rs2736100) is significantly associated with shorter telomere length ( Appendix 1—figure 12 ), whereas the combined effect of SNPs at TERT , TERC and OBFC1 did not reach statistical significance.

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highly significantno p-value reported

While the increased risk appears minor on an individual level, the population-level burden to women’s health arising from these risk loci is highly significant considering the incidence of the condition.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.