Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O<sub>2-</sub>· production in cancer cells.

Br J Cancer · 2018 · PMC6203762 · PMID 30318520

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a strong trendno p-value reported

We also observed a significant acceleration of the clinical progression in exon 5–6 mutant TP53 gene CLL patients as compared with WTp53 CLL, whereas exon 7 mutants show a strong trend of faster clinical progression as compared with WTp53 CLL (Supplementary Figure 2 ).

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a marked trendno p-value reported

We observed a significant acceleration of the clinical progression in frameshift mutant TP53 gene CLL patients as compared with WTp53 CLL, while missense mutants show a marked trend of faster clinical progression as compared with WTp53 CLL (Supplementary Figure 2 ).

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