TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity.

For CD74 and IL-1β the main effect of diet failed to reach statistical significance in either of the HFD-fed groups.

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However, for the markers of CD68, F4/80, MHC II, IL6, and TNFα, this effect was only statistically significant in vehicle-treated HFD-fed mice and did not reach statistical significance in TAK-242-treated HFD-fed mice.

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